Triggering the nanophase separation of albumin through multivalent binding to glycogen for drug delivery in 2D and 3D multicellular constructs

A Radziwon; SK Bhangu; S Fernandes; C Cortez-Jugo; R De Rose; B Dyett; M Wojnilowicz; P Laznickova; J Fric; G Forte; F Caruso; F Cavalieri

Journal article

Triggering the nanophase separation of albumin through multivalent binding to glycogen for drug delivery in 2D and 3D multicellular constructs

A Radziwon, SK Bhangu, S Fernandes, C Cortez-Jugo, R De Rose, B Dyett, M Wojnilowicz, P Laznickova, J Fric, G Forte, F Caruso, F Cavalieri

Nanoscale | Published : 2022

DOI: 10.1039/d1nr08429a

Abstract

Engineered nanoparticles for the encapsulation of bioactive agents hold promise to improve disease diagnosis, prevention and therapy. To advance this field and enable clinical translation, the rational design of nanoparticles with controlled functionalities and a robust understanding of nanoparticle-cell interactions in the complex biological milieu are of paramount importance. Herein, a simple platform obtained through the nanocomplexation of glycogen nanoparticles and albumin is introduced for the delivery of chemotherapeutics in complex multicellular 2D and 3D systems. We found that the dendrimer-like structure of aminated glycogen nanoparticles is key to controlling the multivalent coord..

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University of Melbourne Researchers

Roop Bhangu Author

Christina Cortez-Jugo Author

Rob De Rose Author

Frank Caruso Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by the Australian Research Council (ARC) under a Future Fellowship (F. Cavalieri, FT140100873). F. Caruso acknowledges the award of a National Health and Medical Research Council Senior Principal Research Fellowship (GNT1135806). F. Cavalieri acknowledges the award of an RMIT Vice Chancellor Senior Research Fellowship. This project received funding from the European Union Horizon 2020 Research and Innovation Program under the H2020 Marie Sklodowska-Curie Actions grant agreement no. 872233 ("PEPSAMATE"). This project received funding by the European Regional Development Fund -project ENOCH (no. CZ.02.1.01/0.0/0.0/16_019/0000868), by the European Regional Development Fund Project MAGNET (CZ.02.1.01/0.0/841 0.0/15_003/0000492) and the Ministry of Health of the Czech Republic -DRO (Institute of Hematology and Blood Transfusion, IHBT, 00023736). This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) and Melbourne Histology Platform (MHP) at The University of Melbourne. We acknowledge Haitao Yu for providing help with the STORM analysis.